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Characterization and Biological Activities of Two Copper(II) Complexes with ‎Dipropylenetriamine and Diamine as Ligands

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Fri, 2014-03-14 22:48 — Ismail Warad
Journal Title, Volume, Page: 
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 127 (2014) 225–230
Year of Publication: 
2014
Link: 
http://www.sciencedirect.com/science/article/pii/S1386142514002030
Authors: 
Ismail Warad
Department of Chemistry, An-Najah National University, P.O. Box 7, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, An-Najah National University, P.O. Box 7, Nablus, Palestine
[email protected]
Mousa AL-Noaimi
Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan
Mohammad I. Choudhary
Department of Chemistry, Science College, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Firas F. Awwadi
Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan
Wamidh H. Talib
Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, Jordan
Taibi Ben Hadda
Laboratoire LCM, Faculty of Sciences, University Mohammed 1, Oujda 60000, Morocco
Sammer Yousuf
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Ashraf Sawafta
Biology and Biotechnology Department, AN-Najah National University, P.O. Box 7, Nablus, Palestine
Preferred Abstract (Original): 

Two new mixed-ligand copper(II) complexes, [Cu(dipn)(Nsingle bondN)]Br2(1–2) [dipn = dipropylenetriamine, Nsingle bondN = ethylenediamine (en) (1) and propylenediamine (pn) (2)], have been synthesized. These complexes were characterized by spectroscopic and thermal techniques. Crystal structure for 2 shows a distorted trigonal–bipyramidal geometry around Cu(II) ion with one solvate water molecule. Antimicrobial and antiproliferative assays were conducted to evaluate the biological activities of these complexes. The complexes exhibit a promising antimicrobial effect against an array of microbes at 200 μg/mL concentration. The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152 μM. The absorption spectrum of 2 in water was modeled by time-dependent density functional theory (TD-DFT).

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