Impact of Serum Acetaminophen Concentration on Changes In Serum Potassium, Creatinine And Urea Concentrations Among Patients With Acetaminophen Overdose

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Journal Title, Volume, Page: 
Pharmacoepidemiol Drug Saf. 2011 Feb;20(2):203-8. doi: 10.1002/pds.2060
Year of Publication: 
Zyoud SH
Poison Control And Drug Information Center (PCDIC), An-Najah National University, P.O. Box 7, Nablus, Palestine
Rahmat Awang
WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), Penang, Malaysia
Samah W. Al-Jabi
Clinical Pharmacy Program, College of Pharmaceutical Science, Universiti Sains Malaysia (USM), Penang, Malaysia
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sulaiman SA
WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), Penang, Malaysia
Preferred Abstract (Original): 

Background  Acetaminophen overdose may be accompanied by electrolyte disturbances. The basis for electrolyte change appears to be due to increased fractional urinary electrolyte excretion.
Purpose  This study investigated the impact of serum acetaminophen concentration on changes in serum potassium, creatinine and urea concentrations in patients with acetaminophen overdose.
Methods  This was a retrospective cohort study which included patients admitted to the emergency department and hospital within 24 h of acetaminophen ingestion. The study was conducted over a period of 5 years from 1 January 2004 to 31 December 2008. Data are presented as mean ± SD and as medians (interquartile range) and groups were compared using independent two-tailed Student t-test. Statistical Package for Social Sciences (SPSS) 15 was used for data analysis.
Results  Two hundred and eighty-three patients were studied (44 males and 239 females), mean age 23 ± 7.5 years. Patients who had a serum acetaminophen concentration above a ‘possible toxicity’ treatment line were associated with an elevation in serum creatinine concentration (p = 0.044) and a reduction in the serum potassium concentration (p < 0.001) but were not associated with a reduction in serum urea concentration (p > 0.99). During the study period, 63.3% (179 patients) had serum potassium concentrations less than the normal concentration (3.5 mmol/l) and 31.4% (89 patients) had serum urea concentrations less than the normal concentration (2.5 mmol/l). The serum creatinine concentration in all patients was within the normal range.
Conclusions  Acetaminophen appears to cause a concentration-dependent reduction of potassium concentrations and an elevation of creatinine concentrations of short duration (<24 h) after overdose.

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