Metal ions as Antitumor Complexes-Review

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Journal Title, Volume, Page: 
J. Mater. Environ. Sci. 4 (4) (2013) 542-557, ISSN: 2028-2508, CODEN: JMESCN
Authors: 
Ismail Warad
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Ala’a F. Eftaiha
Department of Chemistry, Science College. King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
Mohammed A. Al-Nuri
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Ahmad I. Husein
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohamed Assal
Department of Chemistry, Science College. King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
Ahmad Abu-Obaid
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Nabil Al-Zaqri
Department of Chemistry, Science College. King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
Taibi Ben Hadda
Lab of Chemical Material, FSO, University Mohammed 1 er, Oujda-60000, Morocco
Belkheir Hammouti
LCAE-URAC18, Faculty of Science, University Mohammed I er, Oujda-60000, Morocco
Preferred Abstract (Original): 

Metal ions are required for many critical functions in humans. Scarcity of some metal ions can lead to disease. Well-known examples include pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient di- etary zinc, and heart disease in infants owing to copper deficiency. The ability to recognize, to understand at the molecular level, and to treat diseases caused by inadequate metal-ion function constitutes an important aspect of medicinal bioinorganic chemistry. Understanding the biochemistry and molecular biology of natural detoxification mechanisms of metals can help in designing and applying chelating agents to treat metals to be excellent antitumor agents for several cancer types.

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