Structural Relationships between the Isoenzymes of Human Placental Alkaline Phosphatase: A Serum Factor Converts M-PLAP to A- And B-PLAP

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Journal Title, Volume, Page: 
Placenta 8, 305-318
Year of Publication: 
Living stone, J.C.
Institute of Genetics, Glasgow University, UK
Abu-Hasan, N.S.
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Clegg, R.J.
Henderson, S.J.
Marsden, H.S.
Sutcliffe, R.G.
Preferred Abstract (Original): 

A protein factor has been found in serum which converts the M form of placental alkaline phosphatase (PLAP) to the A and B forms. The identity of the conversion products has been confirmed by analysis of their dimers and polypeptides. Proteolysis is not implicated in this phenomenon. This report establishes microvillous M-PLAP as the precursor of the A and B forms.