Gentamicin Resistance in Clinical Strains of Enterobacteriaceae Associated With Reduced Gentamicin Uptake

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Journal Title, Volume, Page: 
Folia Microbiol 1998; 43(2): 438-440
Year of Publication: 
1998
Authors: 
Adwan K
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Abu-Hasan N.
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Seven strains of Enterobacteriaceae resistant to gentamicin obtained as representatives of the predominant resistance profiles in the clinical laboratories ofRafeidia andAl-Watani Hospitals in Nablus (Palestine) were included. Five strains showed a broad aminoglycoside resistance profile but contained no evidence of gentamicin acetylation, adenylation, or phosphorylation. Gentamicin uptake in two tested strains was significantly reduced, compared to that of gentamicin-sensitive E. coli (MIC, 0.5 lag/mL). These strains are likely resistant due to a relative reduction of the amount of gentamicin and other aminoglycosides entering the bacterial cell. Two strains showed evidence of adenyltransferase ANT(2")-I activity

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