4-Hydroxy-2-quinolones. 38. Synthesis, structure, and anticonvulsant activity of optically active 1-phenylethylamides of 1-R-4-hydroxy-2-oxo-3-quinolinecarboxylic acids

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Journal Title, Volume, Page: 
Chemistry of Heterocyclic Compounds, Volume 36, Number 1 / January, 2000
Year of Publication: 
Nidal Amin Jaradat
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

A synthesis is reported for optically pure antipodes of 1-phenylethylamides of 1-R-4-hydroxy-2-oxo-3-quinolinecarboxylic acids. An attempt was made to establish the absolute configuration of these products by X-ray diffraction crystallographic analysis. The anticonvulsant activity of the S-enantiomers was studied.