Evaluation of Defined Daily Dose, Percentage of British National Formulary Maximum and Chlorpromazine Equivalents in Antipsychotic Drug Utilization

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Journal Title, Volume, Page: 
Saudi Pharmaceutical Journal, 22, 127 -132
Year of Publication: 
Waleed M. Sweileh
Jihad Bani Odeh
Naser Y. Shraim
Sa’ed H. Zyoud
Ansam F. Sawalha
Samah W. Al-Jabi
Preferred Abstract (Original): 

Objective: The present study was carried out to investigate and compare the three methods for calculating total antipsychotic dose among outpatients with schizophrenia attending primary psychiatric health care centers. The three methods were: Defined Daily Doses (DDDs), chlorpromazine equivalents (CPZeq) and percentages of the British National Formulary (BNF) maximum.

Methodology: Antipsychotic drug dosing data for 250 patients with schizophrenia were investigated by calculating Spearman’s rank correlation coefficients. Factors associated with antipsychoticdose, expressed as DDDs, CPZeq and percentages of the BNF maximum recommended daily dose,were investigated by means of linear regression analysis.

Results: Spearman’s correlation showed that there is a significant relationship between all pairsof the three dosing methods. In all three methods, coherence was strongest when dealing with firstgeneration antipsychotics (FGA). Linear regression analyses showed a high degree of coherence between antipsychotic doses expressed as DDDs, CPZeq and percentages of the BNF maximum recommended daily dose.

Conclusion: All three tested methods are reliable and coherent for calculating antipsychotic dosing.

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