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Synthesis and Characterization of Some Antifungal Active Hydrazones from Combined of Several Functionalized Hydrazides with Di-2-pyridyl ketone

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Mon, 2014-02-17 11:04 — Mohammed Saleem Ali-Shtayeh
Journal Title, Volume, Page: 
Journal of Saudi Chemical Society 2 , 313-318
Year of Publication: 
2007
Link: 
http://faculty.ksu.edu.sa/73826/Documents/18.pdf
Authors: 
Al-Nuri, M.
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus. Palestine
Haroun, A.
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus. Palestine
Warad, I.
Department of Chemistry, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia
Mahfouz, R. M.
Department of Chemistry, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia
Al-Resayes, S.
Department of Chemistry, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia
Ali-Shtayeh, M. S
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus. Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus. Palestine
[email protected]
Preferred Abstract (Original): 

Pyridlhydrazone derivatives [ 1-5 ] were synthesized for the first time by condensation of di-2- pyridyl ketone with different hydrazides individually. The corresponding solid phase hydrazide-hydrazones were collected from acidic-ethanolic medium after 8-10 hours of reflux in very good to excellent yields and purified twice by ethanol/water re-crystallization process. All thesynthesized compounds are characterized by IR, 1 H and 13 C NMR, FAB-MS and other physicalanalyses tests. The microbiological antifungal activity was carried out toward Trichophytonmentagrophytes, Microsporum canis and Trichophyton rubrum.

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