Preferred Abstract (Original):
A series of curcumin derivatives containing heterocyclic moiety have been synthesized
and evaluated for their antibacterial activities. The chemical structures of the synthesized
compounds were veriŸed on the basis of spectral data and elemental analyses. Investigation
of antimicrobial activity of the derivatives demonstrated the ability to inhibit Gram-positive
microorganisms with zone of inhibition ranging from 14-18 mm, MIC ranging between 0.0625
and 0.25 mg/mL. Among all tested derivatives, diazepine 4 exhibited remarkable potency
against Gram-positive bacteria S. aureus. An extensive study is underway to optimize the
effectiveness of diazepine type of compounds and to determine their mode of action.