Purpose
To evaluate the relationship between levels of total testosterone and
total prostate-specific antigen (PSA) in healthy men with PSA<4 ng/mL.
Materials
and Methods
The study comprised 179 men with a mean age of 59.19±12 years who visited
Osmaniye State Hospital, Osmaniye, Turkey, between January 2006 and January
2007 for a routine checkup. The patients were divided into two subgroups:
patients with PSA<2.5 mg/ml (group I, n=160 patients) and patients with PSA
of 2.5 to 4 ng/mL (group II, n=19 patients). The relationship between PSA and
testosterone levels was investigated in both groups and in patients aged <60
years. The mean testosterone level was calculated for patients aged <50
years and was compared with the mean value of patients aged ≥50 years.
Results
In all patients, the mean values for serum PSA and total testosterone
were 1.27±0.88 ng/mL and 404.04±158.86 ng/mL, respectively. No correlation was
detected between serum PSA and testosterone levels in either subgroup (group I,
r=0.072, p=0.363; group II, r=0.031, p=0.900) or in patients aged <60 years
(r=0.032, p=0.72). The mean values of testosterone in patients aged ≥50 years
and in patients aged <50 years were 417.01±163.35 and 344.16±120.21 ng/dL,
respectively (p=0.02).
Conclusions
No impact of testosterone was found on the PSA level in healthy men with
PSA <4 ng/mL. Therefore, a high serum testosterone level may not mandate
adjustment of PSA values. This serum sex hormone showed a significant increment
after the age of 50 years. Further studies including a larger number of
patients should be carried out to confirm these findings
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