Purpose:To assess the effect of oral alpha 1 antagonists on the intraocular pressure (IOP) in rabbits eye. Material
and Methods: Oral selective Alpha 1 blocker(doxasozin) was administered
via an injector daily in rabbits (n=8) with an oral dose of0.08 mg/kg.
Control rabbits (n=4) received equivalent oral doses of vehicle control
of isotonic solution. The IOP of right and left eyes of both experimental and control rabbits were measured immediately before and 2 hours after therapy. Ten observations for each rabbit were recorded. Results:
The mean values of IOP for the right eye before and after therapy were
13.6± 3.8 and 11.1±4.6mmHg respectively (P<0.002). The mean values of
IOP of the left eye before and after therapy were 13.1±4.2 and 10.1±4.4
mmHg respectively (P<0.005). The mean values of IOP for right and
left eye in control group were 15.5±3.8 and 15.4±3.1 respectively. The
control group showed no significant variation in the IOP neither in the
right nor in the left eye, P<0.7, P<0.13, respectively. Conclusion:
Oral alpha 1 adrenergic antagonists result in a significant reduction
in IOP in rabbit’s eye. The data may implicate potential therapeutic
potential for alpha 1 blockers for treatment of patients with high IOP.
Further in vitro and vivostudies are required in a large cohort to
confirm our results