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PSA_and_Testosterone_Serum_Levels_in_The_Middle_East;_Is_There_a_Difference.pdf | 91.46 KB |
OBJECTIVE: we aimed
to evaluate the difference between testosterone and prostate specific antigen
(PSA) serum levels between Arabic and Turkish people.
MATERIAL METHODS: The
study included three separate groups of healthy men from two geographically
distinct regions in Turkey and the third group from Palestinian people. Group 1
included 119 patients with a mean age of 52.73±7.53 years who visited Osmaniye
State Hospital in the east of Turkey for routine check-up between January 2006
and January 2007. Group 2 consisted of 196 patients with a mean age of
50.32±7.84 years who visited the outpatient clinics in Izmir Atatürk Teaching
Hospital in the west of Turkey between July 2008 and July 2009. Group III
consisted of 388, with mean age 51+6 years who visited Palestinian state
hospitals in west bank in Palestine between November 2011 and May. 2012. All
patients were less than 60 year-old with PSA value less than 4 ng/ml and normal
digital rectal examination for those older than 5 years. Any patient with
history of prostatic surgery or has urinary tract infection were excluded. The
mean values of PSA and testosterone were calculated for each groups. The
relationships among testosterone and TPSA levels and patients’ age were
evaluated. RESULTS:
The mean TPSA levels for Group I, Group II and group III were 1.11±0.78 ng/mL
and 1.75±1.06 ng/mL, 1.1+8
ng/ml respectively (p=0.5, p=0.7, p=0.8 respectively). The mean testosterone
levels in Group I (386.4±154.6 ng/dL), Group II (383.9±170.6 ng/dL) and group
III (380±230 ng/L)(p=0.89, p=0.29, p=0.7). There was a positive correlation
between age of the patients and testosterone level (r=0.22, p=0.015) in Group
I; however, in Group II, and group III there were significant negative
correlation between age and serum testosterone levels (r=-0.16, p=0.022 and
r=-0.29, p=˂0.01). Serum testosterone level showed no significant correlation
with TPSA level in all groups (Group 1: r=0.03, p=0.72; Group 2: r=-0.04,
p=0.67, group III r= 0.05, p=0.34).
CONCLUSION: Testosterone or TPSA levels did not change among different nations
or different geographical regions in the middle east. However, the effect of
age on testosterone levels varies according to different geographical regions.