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Metastatic_Penile_Lesions_Secondary_to_Urothelial_Carcinoma_of_the_Bladder_Rare_Cases_and_Bad_Prognosis.pdf | 2.33 MB |
INTRODUCTION: Metastases to the penis from urothelial carcinoma
of the bladder are rare. In the literature, about 300 cases of secondary penile
malignancies were described; 35% out of these cases were from primary neoplasms
of the bladder
MATERIAL-METHODS: Two cases of penile metastasis from primary
blatider urothelial carcinoma were described. The first case was 56-year-old patient
diagnosed to have penile metastasis from microcystic urothelial carcinoma of urinary
bladder. Before developing penile metastases, the patient underwent transurethral
resection of the bladder tumor for two times and administration of intravesical
Bacillus Calrnette-Cuerln (BCG). Later on the patient underwent
radical
cystectomy, penectomy, pelvic lymph node node dissection and ureterocutaneoustomy.
The second case was 56year-old who were diagnosed to have left adrenal mass, multiple
lymphadenopathy, bone metastatic lesion and penile mass. The excisional biopsy of
penile mass was done and medical therapy, for bone metastatic lesion and radiotherapy
for pain were started.
RESULTS: The histologic report of the first case revealed microcystic urothelial
carcinoma of urinary bladder. The pathological stage was pT4bN1M1. The patient died
after 6 months of the operation. This case represent the first of microcystic
variant of urothelial carcinoma which has metastasized to the penis. The
histologic report of the second case showed metastatic urothelial carcinoma. The
patients died within 5 months after beginning of the therapy.
CONCLUSION: Penile metastasis from bladder tumor is associated with high malignancy
tumor and bad prognosis. Aggressive surgical approach is insufficient. Combination
chemotherapy was reported to be beneficial.