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Clinical_Outcomes_Following_Radical_Cystectomy_For_Primary_Non-Urothelial_Carcinoma_of_The_Bladder_Compared_To_Urothelial_Carcinoma_of_The_Bladder.pdf | 2.37 MB |
Purpose: To compare the clinical out
comes after radical cystectomy between patients with urothelial (UC) and nonurothelial(non-UC)
of the bladder
MATERIAL-METHODS:
Total
of 432 patients underwent radical cystectomy with bilateral pelvic lymphadenectomy
for bladder cancer at our department were enrolled. UC was present in the radical
cystectomy specimen in 342 patients. f\Jon-UC histology was present in 90 patients
(21%), including squamous cell carcinoma in 56, adenocarcinoma in 8, undifferentiated
cell carcinoma in 15, and other non-UC subtypes in 11 patients. Mean follow-up
were 23.15+20.83 and 19.67 + 16.27 months for
patients with UC and non-Ut histologies, respectively. Bladder
cancer specific survival was assessed using Kaplan-Meier and log-renk multivariate
Cox regression tests
RESULTS:
Five-year
disease specific survival for' patients with UC was 56.8% and 27.8% non-UC respectively(p=0.003).
The lymph node involvement was significantly higher in patients with non-UC(39.75%)
than in patients with UC(21.23%) of the bladder (p=O.OOI). The stages of the
tumors in patients with non-UC were higher than that of patients with UC (p=O.001).
Bladder cancer specific mortality did not differ significantly between patients
with SCC and UC histologies (p=0.1). However patients with non-UC and non-SCC bladder
cancer were at significantly increased risk for progression and death compared to
patients with UC (p=0.001).
CONCLUSION:
TCC
and SCC seems to have similar survival rate. Patients with Non-UC and non-SCC histology
have the worse prognosis.