Glyconanosomes: Disc-shaped Nanomaterials for the Water Solubilization and Controlled Delivery of Hydrophobic Molecules.

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Journal Title, Volume, Page: 
Acs nano, 7, 2145
Year of Publication: 
2013
Authors: 
mohyeddin assali
Asymmetric Synthesis and Functional Nanosystems Group, Instituto de Investigaciones Químicas (IIQ), CSIC and Universidad de Sevilla, C/Américo Vepucio 49, 41092 Seville, Spain
Current Affiliation: 
Department of pharmacy, faculty of medicine and health sciences, An Najah National University, Nablus, Palestine
Juan-José Cid
Asymmetric Synthesis and Functional Nanosystems Group, Instituto de Investigaciones Químicas (IIQ), CSIC and Universidad de Sevilla, C/Américo Vepucio 49, 41092 Seville, Spain
Manuel Pernía-Leal
Laboratory of Asymmetric Synthesis and Functional Nanosystems, Instituto de Investigaciones Químicas (IIQ), CSIC and Universidad de Sevilla, C/Américo Vepucio 49, 41092 Seville, Spain
Miguel Muñoz-Bravo
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), 41092 Seville, Spain
Inmaculada Fernández
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, C/Profesor García González 2, 41012 Seville, Spain
Ralf E. Wellinger
Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), 41092 Seville, Spain
Noureddin Khiar
Laboratory of Asymmetric Synthesis and Functional Nanosystems, Instituto de Investigaciones Químicas (IIQ), CSIC and Universidad de Sevilla, C/Américo Vepucio 49, 41092 Seville, Spain
Preferred Abstract (Original): 
Herein, we describe the first report on a new class of disk-shaped and quite monodisperse water-soluble nanomaterials that we named glyconanosomes (GNS). GNSs were obtained by sliding out the cylindrical structures formed upon self-organization and photopolymerization of glycolipid 1 on single-walled carbon nanotube (SWCNT) sidewalls. GNSs present a sheltered hydrophobic inner cavity formed by the carbonated tails, surrounded by PEG and lactose moieties. The amphiphilic character of GNSs allows the water solubility of insoluble hydrophobic cargos such as a perylene-bisimide derivative, [60]fullerene, or the anti-carcinogenic drug camptothecin (CPT). GNS/C60 inclusion complexes are able to establish specific interactions between peanut agglutinin (PNA) lectin and the lactose moiety surrounding the complexes, while CPT solubilized by GNS shows higher cytotoxicity toward MCF7-type breast cancer cells than CPT alone. Thus, GNS represents an attractive extension of nanoparticle-based drug delivery systems.
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