Journal of Applied Pharmaceutical Science 5(8):143-146 · August 2015
Year of Publication:
2015
Authors:
Murad N Abualhasan
Mashhour M. Ghanem
Mohyeddin Assali
Abdel naser Zaid
Preferred Abstract (Original):
The
patient package inserts (PPIs) should contain all the required
information for the patient. It must be clear and understandable. There
are several problems with the PPIs including the wrong information,
readability and comprehensibility. Thus the pharmacists have to take an
active role in making sure that patient is aware of important
instruction including correct storage. Five antibiotics namely
Erythromycin ethylsuccinate, Amoxicillin, Cefdinir, Flucloxacillin
sodium and Clarithromycin powder for suspensions, were selected for this study,
these antibiotic were reconstituted as directed on the label and tested
initially and after 7 days when stored at room temperature and in
refrigerator. Several chemical and physical pharmacopeial tests were
performed. The results showed that two of the antibiotic oral
suspensions namely erythromycin ethyl succinate and flucloxacillin
sodium failed the accepted shelf life specification limits when stored
at room temperature while both passes these limits when stored in
refrigerator. Erythromycin ethylsuccinate has failed the tests of taste
and odour while the flucloxacillin sodium has failed the assay test.
Clarithromycin has failed some tests as viscosity, taste and pouring
test when stored in refrigerator while passes all the tests when stored
at room temperature. The study showed the vital role of the pharmacist
to reiterate the important patient package insert instructions specially
those concerned with the storage condition of the drug.