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Research Title: 
Sweet Nanomaterials: Carbohydrate-Coated Carbon Nanotubes and Glyconanosomes as Advanced Nanovectors for Drug Delivery
mohyeddin assali
Juan jose cid
Manuel Pernía-Lea
Inmaculada Fernández
Miguel Muñoz
Ralf Wellinger
Noureddine Khiar
Sun, 2012-12-23
nanoBioMed2013 assali m.pdf302.49 KB
Research Abstract: 

Single-walled carbon nanotubes (SWCNTs)1 have received an unrivalled interest as consequence of their unique structural, mechanical, electrical, and optical properties that make them promising candidates for biomedical applications.2,3 To overcome their inherent insolubility in biological media various approximations, including covalent and non-covalent functionalization, have been developed. Nevertheless, these methods suffer from important drawbacks such as the low stability of the obtained aggregates or the disruption of -electronic character of the CNTs sidewalls. In order to solve these problems, we have recently reported a bottom-up approach based on the supramolecular self-organization of diacetylenic-based glycolipids on the SWCNTs sidewalls, followed by photo-polymerization to form polydiacetylene glycolipid-coated nanotubes.4-7 By using this methodology, the resulting nano-assemblies are water soluble, highly stable and show a biomimetic and multivalent presentation of carbohydrates on their surface, and besides, without altering the physico-chemical properties of the inner tube.7

In the present communication, we are aimed at discussing: a) the synthesis and characterization of glyconanoring-coated SWNTs with 1-type glycolipids (Figure 1), b) their selective binding to lectins (Figure 2A) and their specific aggregation of uropathogenic Escherichia coli bacteria (Figure 2B), and c) the glyconanoring sliding out of the carbon nanotubes to afford a new class of disk-shaped amphiphilic biomaterials named glyconanosomes (GNSs) (Figure 3).

Hence, the ability of GNSs to encapsulate lipophilic molecules will be presented, together with comparative results of in vitro activity of their inclusion complex with camptothecin (CPT) (GNS/CPT) as nanoparticle-based drug delivery systems of 3rd generation for the controlled delivery of CPT in the inhibition of carcinogenic cell proliferation.8