Desalination of brackish water by using reverse osmosis (RO) system powered by solar PV has been till now not tried and examined in Palestine. This paper proposes the rural village Al Maleh for erection and testing of the first PV-powered RO system. Al Maleh is highly qualified for testing of such systems since it has a lot of mineral hot water springs of a salinity of about 3400 ppm. Based on the climate conditions in Al Maleh the paper presents the design of the PV-powered RO water desalination system. The obtained design results can be used for an economic feasibility study of this technology [Mahmoud, M. Techno-economic feasibility of PV-powered water desalination in Palestine. Special Case: Al Maleh Village (under preparation for publish).]. The performance of the designed system is investigated by software simulation. The obtained results show that a daily production of 1 m3 from the brackish water in Al Maleh would require about 820 peak watt of PV generator.