Aims The main aims of the study were to investigate
the prevalence of pre-diabetes and diabetes mellitus (DM) in patients with
schizophrenia, to compare it with those published in the general population,
and to assess significant associations with dysglycemia defined as having
either pre-DM or DM.
Methods A cross-sectional study carried out in 4
governmental primary psychiatric healthcare centers in Northern West-Bank,
Palestine. Fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) were
measured. The World Health Organization (WHO) criteria for defining pre-DM and
DM were used. Dysglycemia was defined as FBG >110 mg/dl.
Results Based
on WHO criteria, 27 patients (10.8%) had diabetes and 34 (13.6%) had
pre-diabetes. The prevalence of DM in patients with schizophrenia was not
significantly higher than that reported in the general population of Palestine.
However, the prevalence of pre-DM was significantly higher than that reported
in the general population of Palestine. Regression analysis showed that advancing
age and abnormal waist circumference were significant predictors of dysglycemia
in patients with schizophrenia.
Conclusions This study confirmed the
high prevalence of dysglycemia in patients with schizophrenia, supporting the
need for monitoring of blood glucose in this category of patients. The presence
of primary risk factors is more important in the development of dysglycemia in
patients with schizophrenia than exposure to antipsychotic drugs.
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Diabetes_Mellitus_in_Patients_with_Schizophrenia_in_West-Bank,_Palestine.pdf | 137.91 KB |