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Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA

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Sun, 2014-03-02 12:19 — Ibrahim Diab Abu-Shqair
Journal Title, Volume, Page: 
Asian Journal of Applied Sciences, Volume 01– Issue 05, December 2013
Year of Publication: 
2013
Authors: 
Ibrahim Abu-Shqair
An-Najah National University;P.O. Box: 7 Nablus, Palestinian Authority
Current Affiliation: 
Ceemistry Department, An-Najah National University, Nablus, Palestine
[email protected]
Nizam Diab
Arab American University- Jenin
Current Affiliation: 
Arab American University- Jenin
[email protected]
Radi Salim
An-Najah National University;P.O. Box: 7 Nablus, Palestinian Authority
Current Affiliation: 
An-Najah National University
Mohammad Al-Subu
An-Najah National University;P.O. Box: 7 Nablus, Palestinian Authority
Current Affiliation: 
An-Najah National University
Preferred Abstract (Original): 

UV-visible spectroscopic methods were used to study the interaction of some fluoroquinolones with calf-thymus DNA. The binding constants of drug-DNA complexes were evaluated and the nature of binding of these drugs with DNA were elucidated. The results suggested that fluoroquinolones bind to DNA through an electrostatic mode of interaction with partial intercalation.

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