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antibacterial-activity-rosmarinus-officinalis-l-alone-and-combination-cefuroxime-against-methicillin.pdf | 222.48 KB |
Objective: To determine the antimicrobial activity of rosemary
(Rosmarinus officinalis L.)
and to investigate the synergistic effects of this extract combined with
ceforuxime against
methicillin-resistant Staphylococcus aureus (MRSA). Methods: The inhibitory and
bactericidal activities of rosemary ethanol extract, alone and in combination
with cefuroxime,were studied. Results: The minimum inhibitory concentrations
(MICs) of the ethanol extract of rosemary were in the range of 0.39 to 3.13
mg/ml. The minimum bactericidal
concentrations (MBCs) were usually equal to or double that MICs. The
antimicrobial activity
of combinations of the ethanol extract of rosemary and cefuroxime indicated
their synergistic
effects against all MRSAs. Conclusion: The present work clearly demonstrates
that rosemary
has a key role in the elevation of susceptibility to β -lactams.