Electrochemical Reduction of Metronidazole and Its Determination in Pharmaceutical Dosage Forms by D.C. Polarography

Journal Title, Volume, Page:

Analytical Letters Volume 19, Issue 3-4, 1986, pages 453-459, DOI:10.1080/00032718608064510

Year of Publication:

1986

Link:

http://www.tandfonline.com/doi/abs/10.1080/00032718608064510#.Uigr0j-56xM

Authors:

Ali Z. Abu Zuhri

Department of Chemistry , Faculty of Science, An-Najah National University, Nablus, Palestine

Suleiman I. Al-khalil

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Medical Laboratory Sciences, Faculty of Science, An-Najah National University, Palestine

[email protected]

Mohammed S. Suleiman

Department of Biology , An-Najah National University, Nablus, West Bank

Preferred Abstract (Original):

A simple d.c. polarographic method has been developed for the determination of metronidazole in dosages forms. In Robinson - Britton buffer (pH 4.38) and in presence of 1.60 × 10⁻³ % Triton X-100, the drug produced a well defined 4-electron polarographic wave followed by another wave of about half the height of the first wave. The current is proportional to the concentration and permits the drug to be determined by d.c. polarography in the concentration range 5.0 × 10⁻⁵ -7.0 × 10⁻⁴ M. Results obtained by the proposed method are in excellent agreement with that provided by the USP-XX method. A rapid, sensitive and accurate polarographic method for the determination of metronidazole in the tablets which are produced locally is proposed.

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Electrochemical Reduction of Metronidazole and Its Determination in Pharmaceutical Dosage Forms by D.C. Polarography