Gentamicin Resistance In Clinical Strains of Enterobacteriaceae Associated With Reduced Gentamicin Uptake

Journal Title, Volume, Page:

Folia Microbiol. 43 (4), 438-440 (1998)

Year of Publication:

1998

Link:

http://www.biomedsearch.com/nih/Gentamicin-resistance-in-clinical-strains/982129...

Authors:

K. ADWAN

Department of Biological Sciences, An-Najah N. University, Nablus, Palestine Fax 972 9 387 982

Current Affiliation:

Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

N. ABU-HASAN

Department of Biological Sciences, An-Najah N. University, Nablus, Palestine Fax 972 9 387 982

Preferred Abstract (Original):

Seven strains of Enterobacteriaceae resistant to gentamicin obtained as representatives of the predominant resistance profiles in the clinical laboratories ofRafeidia andAl-Watani Hospitals in Nablus (Palestine) were included. Five strains showed a broad aminoglycoside resistance profile but contained no evidence of gentamicin acetylation, adenylation, or phosphorylation. Gentamicin uptake in two tested strains was significantly reduced, compared to that of gentamicin-sensitive E. coli (MIC, 0.5 lag/mL). These strains are likely resistant due to a relative reduction of the amount of gentamicin and other aminoglycosides entering the bacterial cell. Two strains showed evidence of adenyltransferase ANT(2")-I activity

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Gentamicin Resistance In Clinical Strains of Enterobacteriaceae Associated With Reduced Gentamicin Uptake