HIV Type 1 Sequences With GGC Substitution In Injecting Drug Users In Greece

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Journal Title, Volume, Page: 
Aids Research And Human Retroviruses Volume 15, Number 7, 1999, Pp. 679-680
Year of Publication: 
1999
Authors: 
Ghaleb Adwan
Department of Biology And Biotechnology, An-Najah N. University, P. O. Box (7)-Nablus Palestine
Current Affiliation: 
Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine
ANNA PAPA
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Sophie Kouidou
Department of Biochemistry, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Stella Alexiou
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Nikolaos Ialissiovas
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Ioannis Itoutsos
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Basilis Kiosses
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Antonis Antoniadis
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki 54006, Greece
Preferred Abstract (Original): 

iT WAS SHOWN that  subtype  B  variants  of  human  immunode- ficiency  virus  type  1  (HIV-1)  from  intravenous  drug  users (IDUs)  differ  from  the  variants  of  homosexual  men  in  several genomic  regions,  including  vpu ,  vpr ,  and  sequences  encoding the  gp120  V3  loop. 1,2 The  most  conserved  was  found  to  be  a synonymous  nucleotide  substitution  in  the  second  glycine codon  at  the  tip  of  the  gp120  V3  loop  (GGC). 1 Several  epi- demiological  studies  w ere  done  among  the  different  risk  groups in  various  European  countries  and  the  United  States.  GGC viruses  have  been  found  in  85%  of  IDUs  in  northern  Europe and  in  45%  of  U.S.  IDUs. 3 The  GGC  pattern  was  not  found  in V3  sequences  obtained  from homosexual  m en  in  various  Eu- ropean  countries  and  the  United  States.

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