Lipid droplets hypertrophy: a crucial determining factor in insulin regulation by adipocytes.

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Journal Title, Volume, Page: 
SCIENTIFIC REPORTS 2015 Mar 6;5:8816. doi: 10.1038/srep08816.
Year of Publication: 
2015
Authors: 
Bahram Sanjabi
Department of Genetics, University Medical Center Groningen, Groningen. The Netherlands
Saad Al-Lahham
Department of Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Current Affiliation: 
Department of biomedical sciences, Faculty of medicine and health sciences, An-Najah University, Nablus, Palestine
Monireh Dashty
Department of Gastroenterology and Hepatology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands. Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Maikel P. Peppelenbosch
Department of Gastroenterology and Hepatology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands
Farhad Rezaee
Department of Gastroenterology and Hepatology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands. Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Behiye Özcan
Department of endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
and more
Preferred Abstract (Original): 

Lipid droplets (LDs) hypertrophy in adipocytes is the main cause of energy metabolic system dysfunction, obesity and its afflictions such as T2D. However, the role of adipocytes in linking energy metabolic disorders with insulin regulation is unknown in humans. Human adipocytes constitutively synthesize and secrete insulin, which is biologically functional. Insulin concentrations and release are fat mass- and LDs-dependent respectively. Fat reduction mediated by bariatric surgery repairs obesity-associated T2D. The expression of genes, like PCSK1 (proinsulin conversion enzyme), GCG (Glucagon), GPLD1, CD38 and NNAT, involved in insulin regulation/release were differentially expressed in pancreas and adipose tissue (AT). INS (insulin) and GCG expression reduced in human AT-T2D as compared to AT-control, but remained unchanged in pancreas in either state. Insulin levels (mRNA/protein) were higher in AT derived from prediabetes BB rats with destructed pancreatic β-cells and controls than pancreas derived from the same rats respectively. Insulin expression in 10 human primary cell types including adipocytes and macrophages is an evidence for extrapancreatic insulin-producing cells. The data suggest a crosstalk between AT and pancreas to fine-tune energy metabolic system or may minimize the metabolic damage during diabetes. This study opens new avenues towards T2D therapy with a great impact on public health.

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