Synthesis and Biological Activities of a Novel Naringin based Heterocyclic Derivatives

Journal Title, Volume, Page:

Mor. J. Chem. 3 N°X (2015) 242-250

Year of Publication:

2016

Link:

Authors:

Nuha shawarb

Department of Chemistry, An-Najah National University, Nablus, Palestine

Current Affiliation:

An-Najah National University, Nablus, Palestine

Preferred Abstract (Original):

Abstract

A number of naringin based heterocyclic derivatives dioxolane and imidazolidine have been synthesized and

evaluated for their antioxidant and biological activities. The chemical structures of the newly synthesized

compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of

antibacterial activity of these compounds was determined by measuring MIC value using broth micro dilution

method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane

showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in

addition this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL,

compared with other semi synthetic derivative.

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An-Najah Staff