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A Synthetic Approach for the Preparation of Rigid Analogs of 1,3-Dipropyl-7-methyl-8-aryl/heteroarylstyryl Xanthines

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Thu, 2014-07-03 12:26 — Abdel Naser Zaid
Journal Title, Volume, Page: 
Synthesis (5): 0773-0777
Year of Publication: 
2001
Link: 
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2001-12766
Authors: 
Abdel Zaid Nasser
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
[email protected]
Pier Giovanni Baraldi
Francesca Fruttarolo
Mojgan Aghazadeh Tabrizi
Maria del Carmen Nuñez
Giampiero Spalluto
Preferred Abstract (Original): 

Tethering the N-8-substituents of N-8-substituted styryl xanthine to N-7 has resulted in a series of conformationally constrained styryl xanthine analogs having the general formula 8. These new compounds have also been evaluated in order to investigate if the A2A adenosine receptor would be able to tolerate such a modification.