The Behavior of Ciprofloxacin at a DNA Modified Glassy Carbon Electrodes

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Journal Title, Volume, Page: 
International journal of electrochemical science. 02/2014; 9(4):1771-1783
Year of Publication: 
Nizam Diab
Arab American University– Jenin; P.O. Box: 240 Jenin, Palestine
Ibrahim Abu-Shqair
An-Najah National University; P.O. Box: 7 Nablus, Palestine
Radi Salim
An-Najah National University; P.O. Box: 7 Nablus, Palestine
Mohammad Al-Subu
An-Najah National University; P.O. Box: 7 Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

The voltammetric behavior of ciprofloxacin was investigated using cyclic voltammetry and differential-pulse anodic stripping voltammetry at bare glassy carbon (GC) electrodes and DNA-modified glassy carbon (DNA-GC) electrodes. For both types of electrodes, only one anodic irreversible wave was observed. A comparison between the current responses for the ciprofloxacin at the modified DNA-GC and unmodified GC electrodes, it was showed that the DNA- modified electrode exhibits a significant enhancement of the voltammetric current response with a better peak shape. Also, the interaction of ciprofloxacin with DNA was studied by using cyclic voltammetry technique at (DNA-GC) electrodes, which showed a weak interaction with a binding constant (K) = 2.89 x 105 M-1. A linear relationship between the peak current and ciprofloxacin concentrations was observed in the range 1.0–10.0 μM, with a slope a detection limit of 0.117 μM, with r = 0.998, and 1.0 μM.

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