A distinct phenotype of childhood leukodystrophy presenting as absence seizure.

1486's picture
Journal Title, Volume, Page: 
PubMed
Year of Publication: 
2014
Authors: 
Dweikat IM
Current Affiliation: 
Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Damsah N
Current Affiliation: 
Department of Pediatrics, Al-Makassed Islamic Charitable Society Hospital, Jerusalem, Israel.
Khalaf R
Current Affiliation: 
Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Leukoencephalopathy refers to any disease of the white matter including hereditary as well as acquired and toxic causes. Inherited leukodystrophies are diseases of myelin including abnormal myelin development, hypomyelination, or degeneration of myelin. We report a 6-year old female who presented with absence seizure at the age of 4 years. Cerebral magnetic resonance imaging (MRI) of the brain showed bilateral periventricular confluent high signal intensity. The seizure responded to anticonvulsant therapy, and the clinical course was characterized by normal development and neurological examination.

KEYWORDS:

Absence seizure; demyelinating; leukodystrophy; white matter